Seth Rogen [Superbad, Pineapple Express, An American Pickle]  is an actor, comedian, writer, producer, and director. Seth talks with Anna about his new movie An American Pickle, lying to the press, wishing he could sing, taking a long ocean voyage...

Sean Hayes [Will & Grace, Smartless] is an actor and producer. He joins Anna to talk about his new podcast Smartless with co-host Jason Bateman and Will Arnett and the thrills of joining the podcasting world. Sean then tells Anna about his tim...

Thomas Middleditch [Silicon Valley, B Positive, Penn Zero] is an actor, comedian, and screenwriter. Thomas joins Anna to talk about a proper smile, the influence of his favorite action movies, cultivating a sense of adventure, how a trip to Austra...

Paul Scheer [The Leauge, The Hot Wives of Orlando, Human Giant, NTSF:SD:SUV, Black Monday] is an actor, comedian, writer, director, producer, and podcaster. Paul and Anna have a heartfelt conversation about the events and decisions that shape a li...

Esther Povitsky [Crazy Ex-Girlfriend, Alone Together, Dollface] is a writer, comedian, actor, and producer. Esther tells Anna about her dream to live in a shed behind her parent's house, how she approaches every day as if it were a Seinfeld episod...

Samantha Irby is an author, comedian, and blogger. She talks with Anna about her latest book Wow, No Thank You, why she doesn't read reviews, what it’s like to see her books in store windows when, to be honest, the value of optimism, the mayor of ...

Chelsea Handler is an author, comedian, actress, television host, producer, and activist. Anna asks Chelsea about her new book Life Will Be The Death of Me (which made Anna cry), why she values independence, childhood ambitions, her passion for ph...

Padma Lakshmi [Top Chef, Taste The Nation] is an author, actress, producer, and TV host. Padma talks with Anna about her timely new Hulu docu-series Taste The Nation, her work with the UN and the ACLU, growing up in New York and Los Angeles, what ...